Figure 3.

(A,B) Tooth radiographs from a normal, 10-year-old male, and from a 10-year-old male patient with X-linked hypophosphatemia (XLH) caused by an inactivating mutation in the PHEX gene. In deciduous molars, note the enlarged pulp chambers (asterisks), the prominent pulp horns, and the radiolucency of the hypomineralized dentin that mineralized prior to the onset of systemic treatment. (C,D) Micro-computed tomography of a crown from the upper-right, second deciduous molar (seen on the panoramic X-ray inset) of a 13-year-old female X-linked hypophosphatemia female patient with a mutation in the PHEX gene. Mineralization voids (the spotty areas indicated by the arrows in panel C accumulating in the dentin near the dentino-enamel junction (DEJ) were rendered in grey using 3D reconstruction software to compile volumetric data from the 2D X-ray “slices,” one of which is depicted in panel D where the mineralization voids appear white. (E,F) Photograph and occlusal X-ray of the upper central right deciduous incisor from a 6-year-old X-linked hypophosphatemia male patient with a mutation of the PHEX gene. A large abscess (arrowhead) is observed related to the incisor root; the tooth was extracted after systemic treatment with antibiotics.