Table 4.
Permeation parameters of the CEG, CG and Different SLN formulations.
| Formulation code | Flux (μg/cm2/h) |
Lag time (h) |
Permeation coefficient (cm/h × 10−3) |
Distribution coefficient (cm2/h × 10−3) |
Enhancement ratio |
|---|---|---|---|---|---|
| CG | 0.317 | 2.8 | 0.0317 | 1.25 | 1 |
| CEG | 1.074 | 2.3 | 0.0925 | 1.56 | 2.917 |
| GMNG-1 | 2.661 | 1.675 | 0.532 | 2.089 | 16.78 |
| GMNG-2 | 3.43 | 1.475 | 0.686 | 2.372 | 21.64 |
| GMNG-3 | 3.94 | 1.17 | 0.788 | 2.991 | 24.85 |
| SANG-1 | 1.63 | 1.9 | 0.326 | 1.842 | 10.28 |
| SANG-2 | 2.03 | 1.5 | 0.406 | 2.333 | 12.8 |
| SANG-3 | 2.529 | 1.3 | 0.505 | 2.692 | 15.93 |
| GLNG-1 | 4.128 | 1.1 | 0.825 | 3.1 | 26.02 |
| GLNG-2 | 4.591 | 1.05 | 0.918 | 3.3 | 28.95 |
| GLNG-3 | 6.363 | 0.4 | 1.25 | 8.7 | 39.43 |
CG: Carbopol gel (Conataing 1% Diclofenac Sodium).
CEG: Comercial Emulgel.