Table 3.
Proteins identified to increase after tocilizumab treatment.
| Protein name | Accession no. | Times of detection | Relative abundance (average) | Increase ratio | Paired t-test P | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| ctr | Before | 4W | 8W | 4W/before | 8W/before | Before versus 4W | Before versus 8W | |||
| Apolipoprotein A-I preproprotein | 4557321 | 7 | 1 | 0.942 | 1.632 | 1.529 | 1.502 | 1.515 | 0.111 | 0.040 |
| Superoxide dismutase 3, extracellular precursor | 118582275 | 7 | 1 | 1.218 | 1.672 | 1.806 | 1.442 | 1.509 | 0.046 | 0.046 |
| Sex hormone-binding globulin isoform 1 precursor | 7382460 | 7 | 1 | 1.496 | 2.061 | 2.337 | 1.376 | 1.510 | 0.013 | 0.027 |
| Lymphatic vessel endothelial hyaluronan receptor 1 | 40549451 | 5 | 1 | 1.299 | 1.713 | 1.994 | 1.340 | 1.505 | 0.028 | 0.037 |
| ABI gene family, member 3 (NESH) binding protein | 33667044 | 5 | 1 | 1.143 | 1.629 | 1.875 | 1.403 | 1.603 | 0.036 | 0.049 |
| Apolipoprotein C-II precursor | 32130518 | 7 | 1 | 1.092 | 1.777 | 1.811 | 1.637 | 1.591 | 0.044 | 0.032 |
| Chitobiase, di-N-acetyl- | 4758092 | 5 | 1 | 0.793 | 1.062 | 1.219 | 1.350 | 1.564 | 0.020 | 0.011 |
| Lysosomal-associated membrane protein 1 | 112380628 | 5 | 1 | 1.417 | 1.648 | 2.239 | 1.220 | 1.581 | 0.017 | 0.037 |
| Selectin L precursor | 4506875 | 5 | 1 | 1.022 | 1.389 | 1.753 | 1.371 | 1.674 | 0.006 | 0.035 |
| Retinol-binding protein 4, plasma precursor | 55743122 | 7 | 1 | 1.150 | 1.797 | 1.920 | 1.607 | 1.637 | 0.016 | 0.041 |
| Cysteine-rich secretory protein 3 | 5174675 | 7 | 1 | 0.799 | 1.224 | 1.325 | 1.529 | 1.685 | 0.002 | 0.004 |
| Melanoma cell adhesion molecule | 71274107 | 7 | 1 | 1.265 | 1.758 | 2.153 | 1.375 | 1.705 | 0.009 | 0.000 |
| Afamin precursor | 4501987 | 7 | 1 | 0.962 | 1.491 | 1.676 | 1.574 | 1.733 | 0.004 | 0.010 |
| Apolipoprotein A-II preproprotein | 4502149 | 7 | 1 | 0.770 | 1.433 | 1.363 | 1.822 | 1.745 | 0.017 | 0.008 |
| Apolipoprotein C-I precursor | 4502157 | 5 | 1 | 1.008 | 1.880 | 1.975 | 1.869 | 1.896 | 0.010 | 0.039 |
| Fumarylacetoacetate hydrolase | 4557587 | 4 | 1 | 1.022 | 1.836 | 1.966 | 1.965 | 2.087 | 0.155 | 0.038 |
Accession number: accession number (gi) in the human RefSeq protein database of the National Center for Biotechnology Information, USA.
Times of detection: the number of samples in which the protein was detected.
Relative abundance: the ratio of the iTRAQ reporter ion to the 114 reporter ion (control).
Increase ratio: the ratio of protein abundance between the second and first samples (4W/before) and between the third and first samples (8W/before).
Bold: increased by more than 1.5-fold.
Paired t-test P: the P value of a paired t-test between the first and second samples (4W) or between the first and third samples (8W).
Bold: P < 0.05.