Table 2.
Upregulation of gene expression by NAMPT, as analyzed by real-time PCR.
| Gene | Fold change (mean) |
SD | SEM | P value |
|---|---|---|---|---|
| EGR1 | 2.422 | 2.306 | 0.421 | <0.001 |
| MMP-1 | 3.781 | 3.116 | 0.569 | <0.001 |
| SYT7 | 4.575 | 7.947 | 1.451 | <0.001 |
| ITPKA | 2.764 | 3.182 | 0.581 | 0.001 |
| CCL2 | 2.285 | 1.346 | 0.246 | <0.001 |
| NTM | 2.124 | 2.460 | 0.449 | <0.001 |
| IGF2BP3 | 1.897 | 0.970 | 0.177 | <0.001 |
| NRP1 | 1.653 | 1.658 | 0.303 | <0.001 |
| KCTD12 | 1.713 | 0.958 | 0.175 | 0.095 |
Effect of NAMPT on gene expression of PDL cells from 10 donors at 1 d. Abbreviations: EGR1: early growth response 1; MMP-1: matrix metalloproteinase-1; SYT7: synaptotagmin 7; ITPKA: inositol 1,4,5-trisphosphate 3-kinase a; CCL2: chemokine, cc motif, ligand 2; NTM: neurotrimin; IGF2BP3: insulin-like growth factor 2 mRNA-binding protein 3; NRP1: neuropilin 1; KCTD12: potassium channel tetramerization domain-containing protein 12.