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. Author manuscript; available in PMC: 2013 Sep 8.
Published in final edited form as: N Engl J Med. 2013 Feb 7;368(6):503–512. doi: 10.1056/NEJMoa1109034

Figure 1. Associations between Each Single-Nucleotide Polymorphism (SNP) and Aortic-Valve Calcium or Mitral Annular Calcium, According to Chromosomal Position.

Figure 1

Manhattan plots show that a single SNP on chromosome 6 (rs10455872) has genomewide significance for aortic-valve calcium (P = 9.0×10−10) (Panel A) and that two SNPs on chromosome 2 (rs17659543 and rs13415097) have genomewide significance for mitral annular calcium (P = 1.5×10−8and P = 1.8×10−8, respectively) (Panel B). The X on the x axis in each panel indicates the X sex chromosome.