Table 1.
Baseline Characteristics of Participants in the Discovery and Replication Cohorts.*
| Characteristic | Discovery Cohorts | Replication Cohorts | |||||||
|---|---|---|---|---|---|---|---|---|---|
| FHS | AGES-RS | MESA | MESA | HNR | MDCS | CCHS | |||
|
White European |
White European |
White European |
African American |
Hispanic American |
Chinese American |
White European |
White European |
White European |
|
| Genotyping platform | Affymetrix, version 5.0 |
Illumina Hu370CNV |
Affymetrix, version 6.0 |
Affymetrix, version 6.0 |
Affymetrix, version 6.0 |
Affymetrix, version 6.0 |
Illumina HumanOmnil- Quad |
LifeSciences ABI 7900HT |
LifeSciences ABI 7900HT |
| Imputation software | MACH | MACH, version 1.0.16 |
IMPUTE, version 2.1.1 |
IMPUTE, version 2.1.1 |
IMPUTE, version 2.1.1 |
IMPUTE, version 2.1.1 |
IMPUTE, version 2.1.2 |
NA | NA |
| Country of origin | United States | Iceland | United States | United States | United States | United States | Germany | Sweden | Denmark |
| No. of participants | 1298 | 3120 | 2527 | 2497 | 2027 | 774 | 745 | 28,193 | 10,400 |
| Age — yr | 60±9 | 76±5 | 63±10 | 61±10 | 61±10 | 62±10 | 60±8 | 58±8 | 56±16 |
| Female sex — no. (%) | 616 (47) | 1811 (58) | 1321 (52) | 1395 (56) | 1094 (54) | 394 (51) | 379 (51) | 17,008 (60) | 5796 (56) |
| Presence of aortic-valve calcium — no. (%) |
510 (39) | 1338 (43) | 397 (16) | 263 (11) | 243 (12) | 67 (9) | 91 (12) | 308 (1)† | 192 (2)† |
| Presence of mitral annular calcium — no. (%) |
259 (20) | NA | 309 (12) | 175 (7) | 197 (10) | 37 (5) | 18 (2) | NA | NA |
*
Plus-minus values are means +SD. AGES-RS denotes Age, Gene/Environment Susceptibility-Reykjavik Study, CCHS Copenhagen City Heart Study, FHS Framingham Heart Study, HNR Heinz Nixdorf Recall Study, MDCS Malmo Diet and Cancer Study, MESA Multi-Ethnic Study of Atherosclerosis, and NA not applicable.
†
Included are data from participants with incident aortic stenosis over a median follow-up period of 14 years in the MDCS and 17 years in the CCHS.