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. Author manuscript; available in PMC: 2013 Sep 8.
Published in final edited form as: N Engl J Med. 2013 Feb 7;368(6):503–512. doi: 10.1056/NEJMoa1109034

Table 2.

Genomewide Significant Associations of Single Nucleotide Polymorphisms (SNPs) with Aortic-Valve and Mitral Annular Calcium.*

SNP Phenotype Chromosome Minor
Allele		 Minor Allele
Frequency		 Odds Ratio
(95% CI)		 P Value No. of
Studies		 Nearest
Gene
rs10455872 Aortic-valve calcium 6 G 0.07 2.05 (1.63–2.57) 9.0×10−10 3 LPA
rs17659543 Mitral annular calcium 2 T 0.16 1.66 (1.39–1.98) 1.5×10−8 2 IL1F9
rs13415097 Mitral annular calcium 2 C 0.16 1.66 (1.39–1.98) 1.8×10−8 2 IL1F9
*

The SNPs were identified in a meta-analysis of data from the FHS, AGES-RS, and MESA during the discovery stage of the study. CI denotes confidence interval.