Table 3.
SNP rs10455872 in LPA and Its Association with Aortic-Valve Calcium in White Europeans in the Discovery and Replication Cohorts.
| Cohort | Minor Allele Frequency |
No. of Participants |
Odds Ratio (95% CI) |
P Value |
|---|---|---|---|---|
| Discovery | ||||
| FHS | 0.07 | 1298 | 2.33 (1.42–3.81) | 7.9×10−4 |
| AGES-RS | 0.06 | 3120 | 2.04 (1.52–2.74) | 1.9×10−6 |
| MESA | 0.06 | 2527 | 1.80 (1.09–2.97) | 0.022 |
| Pooled FHS, AGES-RS, and MESA cohorts* |
0.07 | 6942 | 2.05 (1.63–2.57) | 9.0×10−10 |
| Replication | 0.06 | 745 | 2.04 (1.13–3.67) | 0.018 |
| HNR | ||||
| Pooled FHS, AGES-RS, MESA, and HNR cohorts† |
0.07 | 7687 | 2.05 (1.66–2.53) | 2.8×10−11 |
*
The method of genomic control was used to correct for heterogeneity among populations in these cohorts (i.e., population stratification).
†
No genomic-control correction was used for the meta-analysis of these pooled cohorts.