Table I.
Patient ID | Cancer type | Age at treatment (years) | Dose to testes (Gy) | Chemotherapy (yes/no) | Number of offspring analysed | Time from end of treatment to offspring birth (years) |
---|---|---|---|---|---|---|
T03 | Rhabdomyosarcoma | 9 | 0.25 | yes | 2 | 17, 20 |
T05 | Hodgkin's disease | 10 | 1.20 | no | 2 | 16, 18 |
T08 | Neuroblastoma | <1 | 0.21 | no | 1 | 29 |
T09 | Wilms' tumour | 7 | 0.17 | yes | 2 | 21, 22 |
T14 | Ewing's sarcoma | 7 | 0.30 | no | 2 | 28, 31 |
T15 | Pineocytoma | 19 | 0.23 | no | 1 | 9 |
T17 | Germinoma | 17 | 0.17 | yes | 1 | 5 |
T18 | Malignant schwannoma | 19 | <0.01 | no | 2 | 13, 15 |
T19 | Hodgkin's disease | 17 | 0.04 | no | 2 | 6, 7 |
T22 | Wilms' tumour | 1 | 0.21 | yes | 1 | 27 |
T23 | Wilms' tumour | 5 | 0.20 | yes | 2 | 21, 26 |
T29 | Hodgkin's disease* | 27 | 0.04, 0.15 | no | 2 | <1, 3 |
T30 | Hodgkin's disease | 14 | 0.34 | yes | 2 | 13, 16 |
T36 | Malignant lymphoma | 18 | 0.04 | yes | 2 | 10, 16 |
T40 | Malignant lymphoma | 10 | 0.05 | yes | 2 | 17, 22 |
T42 | Hodgkin's disease | 27 | 0.03 | no | 2 | 6, 8 |
T43 | Hodgkin's disease | 29 | 0.07 | yes | 1 | 10 |
T44 | Malignant lymphoma | 17 | 0.08 | no | 2 | 10, 12 |
T47 | Hodgkin's disease | 31 | 0.03 | yes | 1 | 4 |
T48 | Hodgkin's disease | 20 | 0.04 | yes | 3 | 14, 17, 22 |
T49 | Hodgkin's disease | 29 | 0.03 | no | 2 | 7, 9 |
T50 | Hodgkin's disease | 5 | 0.08 | yes | 2 | 24, 31 |
T51 | Malignant lymphoma | 11 | 0.02 | no | 2 | 16, 18 |
T52 | Hodgkin's disease | 14 | 0.04 | no | 2 | 10, 12 |
T53 | Testis (seminoma) | 33 | 1.50 | no | 2 | 4, 6 |
T55 | Testis (teratoma) | 25 | 1.70 | no | 1 | 3 |
T56 | Testis (seminoma) | 28 | 0.45 | no | 4 | 2, 5, 7, 11 |
T57 | Testis (teratocarcinoma) | 30 | 2.40 | yes | 1 | 4 |
T58 | Testis (seminoma) | 25 | 4.10 | no | 2 | 5, 12 |
T59 | Testis (seminoma) | 29 | 2.00 | no | 1 | 2 |
T60 | Testis (seminoma) | 28 | 1.30 | no | 1 | 4 |
T61 | Testis (embryonal carcinoma) | 29 | 6.40 | no | 1 | 13 |
T62 | Testis (seminoma) | 26 | 1.30 | no | 2 | 3, 4 |
T63 | Testis (embryonal carcinoma) | 23 | 2.10 | no | 3 | 7, 9, 11 |
T64 | Testis (seminoma) | 26 | 1.80 | no | 2 | 2, 5 |
T65 | Hodgkin's disease | 17 | 0.03 | no | 1 | 16 |
T66 | Testis (seminoma) | 22 | 2.00 | no | 2 | 3, 6 |
T67 | Hodgkin's disease | 21 | 1.50 | no | 3 | 7, 11, 16 |
T68 | Testis (seminoma) | 29 | 1.80 | no | 1 | 17 |
T70 | Testis (seminoma) | 24 | 1.80 | no | 2 | 4, 6 |
T71 | Malignant lymphoma | 7 | 2.40 | no | 1 | 18 |
T72 | Testis (seminoma) | 24 | 2.50 | no | 1 | 7 |
T73 | Testis (embryonal carcinoma) | 23 | 2.40 | yes | 3 | 4, 6, 9 |
T74 | Testis (seminoma) | 27 | 2.00 | no | 2 | 4, 7 |
T75 | Testis (seminoma) | 30 | 1.80 | no | 2 | 3, 8 |
T76 | Testis (embryonal carcinoma with choriocarcinoma) | 27 | 2.20 | yes | 1 | 5 |
T77 | Testis (seminoma) | 30 | 4.90 | no | 1 | 7 |
T78 | Testis (teratoma) | 26 | 2.20 | no | 3 | 4, 8, 10 |
T79 | Testis (seminoma) | 26 | 1.30 | no | 2 | 3, 7 |
T80 | Testis (seminoma) | 32 | 0.47 | no | 2 | 4, 10 |
T81 | Hodgkin's disease | 30 | 0.02 | yes | 1 | 4 |
T82 | Testis (seminoma) | 30 | 1.80 | no | 1 | 8 |
T83 | Hodgkin's disease | 31 | 0.07 | yes | 1 | 2 |
T84 | Malignant lymphoma | 29 | 0 | no | 1 | 1 |
T85 | Testis (seminoma) | 27 | 5.40 | no | 3 | 4, 7, 9 |
T86 | Testis (seminoma) | 22 | High | no | 2 | 19, 21 |
T87 | Testis (seminoma) | 33 | 0.52 | no | 1 | <1 |
T89 | Hodgkin's disease | 22 | 0.10 | yes | 1 | 6 |
T90 | Testis (seminoma) | 32 | 4.00 | no | 1 | 5 |
T91 | Hodgkin's disease | 22 | 0.03 | yes | 1 | 12 |
T92 | Hodgkin's disease | 28 | 0.04 | no | 4** | 2, 5, 11, 14 |
T93 | Testis (seminoma) | 28 | 0.45 | no | 2 | 2, 4 |
T94 | Testis (seminoma) | 31 | 1.80 | no | 2 | 7, 11 |
T95 | Testis (teratocarcinoma) | 25 | 2.50 | yes | 2 | 9, 11 |
T96 | Testis (seminoma) | 28 | 4.20 | no | 1 | 9 |
T97 | Testis (embryonal carcinoma and teratoma) | 27 | 0.51 | yes | 1 | 4 |
T98 | Testis (embryonal carcinoma) | 32 | 2.40 | yes | 2 | 15, 18 |
T99 | Testis (seminoma) | 28 | 1.80 | no | 2 | 3, 8 |
T100 | Hodgkin's disease | 30 | 0.02 | yes | 2 | 4, 6 |
T101 | Testis (embryonal carcinoma) | 25 | 2.30 | yes | 2 | 10, 14 |
T102 | Testis (embryonal carcinoma and teratoma) | 24 | 2.00 | no | 1 | 5 |
T103 | Testis (embryonal carcinoma) | 28 | 2.40 | no | 1 | 17 |
T104 | Testis (seminoma) | 29 | 1.80 | no | 1 | 3 |
T105 | Hodgkin's disease | 23 | 0.23 | no | 2 | 4, 9 |
T106 | Testis (seminoma) | 30 | 1.80 | no | 1 | 8 |
Mean age at treatment | 23 | |||||
Mean preconceptional testicular dose for all offspring (excluding T86) | 1.23 | |||||
Number offspring with parental chemotherapy yes/no | 39/90 | |||||
Total number of offspring | 129 | |||||
Mean time from treatment to birth of offspring | 10 |
First offspring conceived at end of first treatment period, second offspring conceived after all treatment completed.
Family 92 consisted of two offspring from each of two mothers.