Table I.
Male Cancer Survivors. Data on cancer type, age at treatment, testicular dose, presence or absence of chemotherapy, number of offspring analysed per family, time from end of treatment to birth of offspring.
| Patient ID | Cancer type | Age at treatment (years) | Dose to testes (Gy) | Chemotherapy (yes/no) | Number of offspring analysed | Time from end of treatment to offspring birth (years) |
|---|---|---|---|---|---|---|
| T03 | Rhabdomyosarcoma | 9 | 0.25 | yes | 2 | 17, 20 |
| T05 | Hodgkin's disease | 10 | 1.20 | no | 2 | 16, 18 |
| T08 | Neuroblastoma | <1 | 0.21 | no | 1 | 29 |
| T09 | Wilms' tumour | 7 | 0.17 | yes | 2 | 21, 22 |
| T14 | Ewing's sarcoma | 7 | 0.30 | no | 2 | 28, 31 |
| T15 | Pineocytoma | 19 | 0.23 | no | 1 | 9 |
| T17 | Germinoma | 17 | 0.17 | yes | 1 | 5 |
| T18 | Malignant schwannoma | 19 | <0.01 | no | 2 | 13, 15 |
| T19 | Hodgkin's disease | 17 | 0.04 | no | 2 | 6, 7 |
| T22 | Wilms' tumour | 1 | 0.21 | yes | 1 | 27 |
| T23 | Wilms' tumour | 5 | 0.20 | yes | 2 | 21, 26 |
| T29 | Hodgkin's disease* | 27 | 0.04, 0.15 | no | 2 | <1, 3 |
| T30 | Hodgkin's disease | 14 | 0.34 | yes | 2 | 13, 16 |
| T36 | Malignant lymphoma | 18 | 0.04 | yes | 2 | 10, 16 |
| T40 | Malignant lymphoma | 10 | 0.05 | yes | 2 | 17, 22 |
| T42 | Hodgkin's disease | 27 | 0.03 | no | 2 | 6, 8 |
| T43 | Hodgkin's disease | 29 | 0.07 | yes | 1 | 10 |
| T44 | Malignant lymphoma | 17 | 0.08 | no | 2 | 10, 12 |
| T47 | Hodgkin's disease | 31 | 0.03 | yes | 1 | 4 |
| T48 | Hodgkin's disease | 20 | 0.04 | yes | 3 | 14, 17, 22 |
| T49 | Hodgkin's disease | 29 | 0.03 | no | 2 | 7, 9 |
| T50 | Hodgkin's disease | 5 | 0.08 | yes | 2 | 24, 31 |
| T51 | Malignant lymphoma | 11 | 0.02 | no | 2 | 16, 18 |
| T52 | Hodgkin's disease | 14 | 0.04 | no | 2 | 10, 12 |
| T53 | Testis (seminoma) | 33 | 1.50 | no | 2 | 4, 6 |
| T55 | Testis (teratoma) | 25 | 1.70 | no | 1 | 3 |
| T56 | Testis (seminoma) | 28 | 0.45 | no | 4 | 2, 5, 7, 11 |
| T57 | Testis (teratocarcinoma) | 30 | 2.40 | yes | 1 | 4 |
| T58 | Testis (seminoma) | 25 | 4.10 | no | 2 | 5, 12 |
| T59 | Testis (seminoma) | 29 | 2.00 | no | 1 | 2 |
| T60 | Testis (seminoma) | 28 | 1.30 | no | 1 | 4 |
| T61 | Testis (embryonal carcinoma) | 29 | 6.40 | no | 1 | 13 |
| T62 | Testis (seminoma) | 26 | 1.30 | no | 2 | 3, 4 |
| T63 | Testis (embryonal carcinoma) | 23 | 2.10 | no | 3 | 7, 9, 11 |
| T64 | Testis (seminoma) | 26 | 1.80 | no | 2 | 2, 5 |
| T65 | Hodgkin's disease | 17 | 0.03 | no | 1 | 16 |
| T66 | Testis (seminoma) | 22 | 2.00 | no | 2 | 3, 6 |
| T67 | Hodgkin's disease | 21 | 1.50 | no | 3 | 7, 11, 16 |
| T68 | Testis (seminoma) | 29 | 1.80 | no | 1 | 17 |
| T70 | Testis (seminoma) | 24 | 1.80 | no | 2 | 4, 6 |
| T71 | Malignant lymphoma | 7 | 2.40 | no | 1 | 18 |
| T72 | Testis (seminoma) | 24 | 2.50 | no | 1 | 7 |
| T73 | Testis (embryonal carcinoma) | 23 | 2.40 | yes | 3 | 4, 6, 9 |
| T74 | Testis (seminoma) | 27 | 2.00 | no | 2 | 4, 7 |
| T75 | Testis (seminoma) | 30 | 1.80 | no | 2 | 3, 8 |
| T76 | Testis (embryonal carcinoma with choriocarcinoma) | 27 | 2.20 | yes | 1 | 5 |
| T77 | Testis (seminoma) | 30 | 4.90 | no | 1 | 7 |
| T78 | Testis (teratoma) | 26 | 2.20 | no | 3 | 4, 8, 10 |
| T79 | Testis (seminoma) | 26 | 1.30 | no | 2 | 3, 7 |
| T80 | Testis (seminoma) | 32 | 0.47 | no | 2 | 4, 10 |
| T81 | Hodgkin's disease | 30 | 0.02 | yes | 1 | 4 |
| T82 | Testis (seminoma) | 30 | 1.80 | no | 1 | 8 |
| T83 | Hodgkin's disease | 31 | 0.07 | yes | 1 | 2 |
| T84 | Malignant lymphoma | 29 | 0 | no | 1 | 1 |
| T85 | Testis (seminoma) | 27 | 5.40 | no | 3 | 4, 7, 9 |
| T86 | Testis (seminoma) | 22 | High | no | 2 | 19, 21 |
| T87 | Testis (seminoma) | 33 | 0.52 | no | 1 | <1 |
| T89 | Hodgkin's disease | 22 | 0.10 | yes | 1 | 6 |
| T90 | Testis (seminoma) | 32 | 4.00 | no | 1 | 5 |
| T91 | Hodgkin's disease | 22 | 0.03 | yes | 1 | 12 |
| T92 | Hodgkin's disease | 28 | 0.04 | no | 4** | 2, 5, 11, 14 |
| T93 | Testis (seminoma) | 28 | 0.45 | no | 2 | 2, 4 |
| T94 | Testis (seminoma) | 31 | 1.80 | no | 2 | 7, 11 |
| T95 | Testis (teratocarcinoma) | 25 | 2.50 | yes | 2 | 9, 11 |
| T96 | Testis (seminoma) | 28 | 4.20 | no | 1 | 9 |
| T97 | Testis (embryonal carcinoma and teratoma) | 27 | 0.51 | yes | 1 | 4 |
| T98 | Testis (embryonal carcinoma) | 32 | 2.40 | yes | 2 | 15, 18 |
| T99 | Testis (seminoma) | 28 | 1.80 | no | 2 | 3, 8 |
| T100 | Hodgkin's disease | 30 | 0.02 | yes | 2 | 4, 6 |
| T101 | Testis (embryonal carcinoma) | 25 | 2.30 | yes | 2 | 10, 14 |
| T102 | Testis (embryonal carcinoma and teratoma) | 24 | 2.00 | no | 1 | 5 |
| T103 | Testis (embryonal carcinoma) | 28 | 2.40 | no | 1 | 17 |
| T104 | Testis (seminoma) | 29 | 1.80 | no | 1 | 3 |
| T105 | Hodgkin's disease | 23 | 0.23 | no | 2 | 4, 9 |
| T106 | Testis (seminoma) | 30 | 1.80 | no | 1 | 8 |
| Mean age at treatment | 23 | |||||
| Mean preconceptional testicular dose for all offspring (excluding T86) | 1.23 | |||||
| Number offspring with parental chemotherapy yes/no | 39/90 | |||||
| Total number of offspring | 129 | |||||
| Mean time from treatment to birth of offspring | 10 | |||||
*
First offspring conceived at end of first treatment period, second offspring conceived after all treatment completed.
**
Family 92 consisted of two offspring from each of two mothers.