Table III.
Minisatellite mutations detected at eight hypervariable minisatellite loci for 170 offspring from 100 cancer survivor families. Is this table somewhat confusing in that the top starts with exposed fathers whereas the bottom starts with the unexposed mothers? Reverse one?
Exposed Fathers (n = 75) (Male Cancer Survivors) | Unexposed Fathers (n = 25) (Partners of Female Survivors) | p | |||||
---|---|---|---|---|---|---|---|
|
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Locus | No. of Mutations | No. of Alleles | Mutation Rate (%) | No. of Mutations | No. of Alleles | Mutation Rate (%) | |
B6.7 | 9 | 115 | 7.8 | 2 | 36 | 5.6 | 1.00 |
CEB1 | 25 | 124 | 20.2 | 5 | 38 | 13.2 | 0.47 |
CEB15 | 4 | 125 | 3.2 | 2 | 38 | 5.3 | 0.62 |
CEB25 | 5 | 128 | 3.9 | 3 | 37 | 8.1 | 0.38 |
CEB36 | 3 | 122 | 2.5 | 0 | 32 | 0.0 | 1.00 |
MS1 | 6 | 128 | 4.7 | 4 | 38 | 10.5 | 0.24 |
MS31 | 4 | 127 | 3.1 | 1 | 37 | 2.7 | 1.00 |
MS32 | 0 | 129 | 0.0 | 0 | 39 | 0.0 | 1.00 |
Total | 56 | 998 | 5.6 | 17 | 295 | 5.8 | 0.89 |
Mean Mutation Rate | 5.7 | 5.7 | |||||
| |||||||
Unexposed Mothers (n = 76*) (Partners of Male Survivors) | Exposed Mothers (n = 25) (Female Cancer Survivors) | ||||||
| |||||||
B6.7 | 4 | 117 | 3.4 | 1 | 36 | 2.8 | 1.00 |
CEB1 | 3 | 118 | 2.5 | 0 | 38 | 0.0 | 1.00 |
CEB15 | 2 | 124 | 1.6 | 0 | 39 | 0.0 | 1.00 |
CEB25 | 3 | 126 | 2.4 | 0 | 39 | 0.0 | 1.00 |
CEB36 | 0 | 117 | 0.0 | 2 | 38 | 5.3 | 0.06 |
MS1 | 8 | 129 | 6.2 | 2 | 39 | 5.1 | 1.00 |
MS31 | 0 | 127 | 0.0 | 0 | 37 | 0.0 | 1.00 |
MS32 | 1 | 129 | 0.8 | 0 | 38 | 0.0 | 1.00 |
Total | 21 | 987 | 2.1 | 5 | 304 | 1.6 | 0.82 |
Mean Mutation Rate | 2.1 | 1.6 |
p = probability Fisher's exact test, two-tailed;
Family 92 consisted of four offspring from two different mothers