Table 2.
Quantification of selected proteins measured by SRM in plasma of ovarian cancer (OC) patients and patients with benign ovarian tumors (BOT). Statistical analysis was performed using a linear mixed effect model implemented in SRMstats (27). The proteins were selected because they are either part of the OVA1 biomarker panel (OVA1), have been proposed as biomarker candidates for ovarian cancer (literature) or because they functionally interact with epigenetically silenced or mutated genes in ovarian cancer (network).
| Protein | Gene symbol | Fold-change | P-value | Significant | Source (regulation) | Publication |
|---|---|---|---|---|---|---|
| AACT | SERPINA3 | 1.54 | 7.18E-10 | yes | literature (up), network | (73-75) |
| APOA1 | APOA1 | 0.86 | 0.0016 | yes | OVA1 (down) | (53, 55, 56) |
| APOE | APOE | 0.83 | 1.39E-04 | yes | literature (up) | (75) |
| B2MG | B2M | 1.19 | 2.51E-04 | yes | OVA1 (up) | (53, 55, 56) |
| C1R | C1R | 1.16 | 1.19E-05 | yes | network | |
| CFAB | CFB | 1.29 | 8.22E-06 | yes | network | |
| CO5 | C5 | 1.19 | 1.27E-05 | yes | network | |
| CO6 | C6 | 1.11 | 0.0026 | yes | network | |
| CO7 | C7 | 1.22 | 3.55E-04 | yes | network | |
| GELS | GSN | 0.77 | 1.39E-04 | yes | network | |
| HPT | HP | 1.67 | 0 | yes | literature (up), network | (56, 75) |
| IC1 | SERPING1 | 1.18 | 0.0050 | yes | literature (up), network | (73) |
| ITIH4 | ITIH4 | 1.18 | 1.77E-05 | yes | literature (up) | (55, 73, 74) |
| RET4 | RBP4 | 0.76 | 4.11E-07 | yes | network | |
| SHBG | SHBG | 1.47 | 6.96E-11 | yes | network | |
| TETN | CLEC3B | 0.78 | 3.02E-08 | yes | literature (down) | (76) |
| THBG | SERPINA7 | 1.20 | 1.24E-04 | yes | network | |
| TRFE | TF | 0.84 | 2.79E-08 | yes | OVA1 (down) | (53, 55, 56) |
| TTHY | TTR | 0.70 | 2.73E-08 | yes | OVA1 (down) | (53, 55, 56) |
| A2MG | A2M | 0.89 | 0.0605 | no | network | |
| APOA | LPA | 1.33 | 0.0605 | no | literature (up) | (73) |
| APOB | APOB | 1.04 | 0.4771 | no | literature (down) | (77) |
| C1QA | C1QA | 0.98 | 0.6961 | no | network | |
| C1QB | C1QB | 1.08 | 0.0362 | no | literature (up), network | (73) |
| C1QC | C1QC | 0.97 | 0.6555 | no | network | |
| CADH5 | CDH5 | 1.01 | 0.8670 | no | network | |
| CLUS | CLU | 0.95 | 0.0626 | no | literature (up) | (74, 78, 79) |
| CO3 | C3 | 1.09 | 0.0163 | no | network | |
| CO4A | C4A | 1.05 | 0.4255 | no | network | |
| FN1 | FN1 | 0.82 | 0.0181 | no | network | |
| IGF2 | IGF2 | 0.97 | 0.5384 | no | network | |
| PLMN | PLG | 1.00 | 0.9690 | no | network | |
| THRB | F2 | 1.00 | 0.9598 | no | network | |
| VTNC | VTN | 1.03 | 0.4771 | no | literature (up), network | (80) |