Aversive |
Disruption—Amnesia |
Protein synthesis inhibition—Anisomycin |
Lateral amygdala |
Nader et al., 2000a; Duvarci and Nader, 2004
|
|
Cued fear conditioning |
|
|
NMDA antagonism—MK-801 |
Systemic |
Ben Mamou et al., 2006; Lee et al., 2006b
|
|
|
|
BLA |
Ben Mamou et al., 2006
|
|
|
B-adrenergic antagonism—propranolol |
Lateral amygdala |
Debiec and Ledoux, 2004, 2006
|
|
|
|
Systemic |
Kindt et al., 2009; Soeter and Kindt, 2012; Kindt and Soeter, 2013
|
|
|
Protein kinase A inhibitor |
Lateral amygdala |
Tronson et al., 2006
|
|
|
Cannabinoid CB1 agonist—WIN55212-2 |
BLA |
Lin et al., 2006
|
|
Contextual fear conditioning |
Protein synthesis inhibition—Anisomycin |
Hippocampus |
Debiec et al., 2002
|
|
|
Transcription factor inhibition—Zif268 |
Hippocampus |
Lee et al., 2004
|
|
|
|
Amygdala |
Lee et al., 2004; Malkani et al., 2004; Maddox et al., 2011
|
|
|
NMDA antagonism—AP5 |
Hippocampus |
Lee and Hynds, 2012
|
|
|
NMDA antagonism—MK-801 |
Systemic |
Charlier and Tirelli, 2011
|
|
|
β-adrenergic antagonism—Propranolol |
Systemic |
Abrari et al., 2008
|
|
|
GABAA agonist - midazolam |
Systemic |
Bustos et al., 2006; Zhang and Cranney, 2008
|
|
Inhibitory avoidance |
Protein synthesis inhibition—Anisomycin |
Amygdala |
Milekic et al., 2007
|
|
|
β-adrenergic antagonism—Propranolol |
Systemic |
Przybyslawski et al., 1999
|
|
|
Acetylcholine antagonist—α 7 nicotinic antagonist |
Hippocampus |
Boccia et al., 2010
|
|
|
Transcription inhibitor—NF-κB |
Hippocampus |
Boccia et al., 2007; Jobim et al., 2012
|
|
|
mTOR inhibition |
Hippocampus and BLA |
Jobim et al., 2012
|
|
|
|
BLA |
Pedroso et al., 2013
|
|
Conditioned taste aversion |
Protein synthesis inhibition—Cyclohexamide |
Systemic |
Flint and Marino, 2007
|
|
|
Anisomycin |
Insular cortex |
Eisenberg et al., 2003; Bahar et al., 2004
|
|
|
Protein kinase inhibition |
BLA |
Koh and Bernstein, 2003
|
|
|
Cannabinoid CB1 agonist—WIN55212-2 |
Insular cortex |
Kobilo et al., 2007
|
|
Enhancement |
NMDA agonism—d-cycloserine |
Systemic |
Lee et al., 2006b
|
|
Cued fear conditioning |
Cannabinoid CB1 agonist—WIN55212-2 |
Hippocampus |
de Oliveira Alvares et al., 2008
|
|
Contextual fear conditioning |
NMDA agonism—d-cycloserine |
Systemic |
Yamada et al., 2009
|
Appetitive |
Disruption—Amnesia |
Protein synthesis inhibition—Anisomycin |
BLA |
Lee et al., 2005
|
|
Conditioned reinforcement |
|
|
Transcription factor inhibition—Zif268 |
BLA |
Lee et al., 2005
|
|
|
NMDA antagonist—AP5 |
BLA |
Milton et al., 2008a
|
|
|
MK-801 |
Systemic |
Lee and Everitt, 2008a
|
|
|
β-adrenergic antagonism—Propranolol |
Systemic |
Milton et al., 2008b
|
|
Sign-tracking and Pavlovian—Instrumental transfer |
NMDA antagonist—MK-801 |
Systemic |
Lee and Everitt, 2008a,c; Milton et al., 2008a, 2012
|
|
|
B-adrenergic antagonism—Propranolol (cocaine sign tracking only) |
Systemic |
Milton and Everitt, 2010
|
|
Goal tracking |
NMDA antagonist—MK-801 |
Systemic |
Reichelt and Lee, 2012
|
|
Conditioned place preference |
Protein synthesis inhibition—Anisomycin |
BLA |
Milekic et al., 2006
|
|
|
NMDA antagonist—AP5 |
Hippocampus |
Sakurai et al., 2007
|
|
|
MK-801 |
Systemic |
Sadler et al., 2007; Brown et al., 2008; Alaghband and Marshall, 2012
|
|
|
β-adrenergic antagonism—Propranolol |
Systemic |
Bernardi et al., 2006; Robinson and Franklin, 2007a,b; Fricks-Gleason and Marshall, 2008; Achterberg et al., 2012
|
|
|
GABAA agonist—Midazolam |
Systemic |
Robinson and Franklin, 2010
|
|
|
Muscarinic acetylcholine agonist—Scopolamine |
Systemic |
Kelley et al., 2007
|
|
|
Transcription inhibitor—NF-κB |
Intraventricular |
Yang et al., 2011
|
|
|
-cdK5 |
BLA |
Li et al., 2010
|
|
|
-ERK |
Frontal cortex |
Li et al., 2008
|
|
Odor-reward discrimination |
NMDA antagonist—AP5 |
Intraventricular |
Torras-Garcia et al., 2005
|
|
Enhancement |
NMDA agonist—d-cycloserine |
BLA |
Lee et al., 2009
|
|
Conditioned reinforcement |
|
Odor-reward discrimination |
NMDA agonist—d-cycloserine |
BLA |
Portero-Tresserra et al., 2013
|
|
Conditioned place preference |
NMDA agonist—d-cycloserine |
Systemic |
Kelley et al., 2007
|