Table 2.

Relation of the neuropathologies with rate of decline in four cognitive systems^*.

Term	Estimate (SE) p
Episodic memory
Tangles	–0.0045 (0.0009) p < 0.001
Amyloid	Ns
Gross infarcts	Ns
Microinfarcts	Ns
Neocortical Lewy bodies	Ns
Semantic memory
Tangles	–0.0031 (0.0006) p < 0.001
Amyloid	–0.0012 (0.0006) p = 0.044
Gross infarcts	–0.0139 (0.0057) p = 0.016
Microinfarcts	Ns
Neocortical Lewy bodies	–0.0303 (0.0094) p = 0.001
Working memory
Tangles	Ns
Amyloid	–0.0021 (0.0007) p = 0.004
Gross infarcts	Ns
Microinfarcts	Ns
Neocortical Lewy bodies	–0.0221 (0.0109) p = 0.042
Perceptual speed
Tangles	Ns
Amyloid	Ns
Gross infarcts	Ns
Microinfarcts	Ns
Neocortical Lewy bodies	–0.0784 (0.0160) p < 0.001

^*Derived from random coefficient models including terms for age, sex, education, time, all of the neuropathologies, and the interactions of demographics and the neuropathologies with time.