FIGURE 1.

Schematic of somatostatin signaling, pathological regulators and biological functions relevant to affect regulation. Somatostatin pathway activity is responsive to (left panel), and regulates (right panel), several biological events, and molecular and cellular properties that have been linked to mood disturbances. Somatostatin and somatostatin-expressing interneurons are key conduits for regulating incoming information and pyramidal cell function. In contrast, other GABA neurons subtypes targeting the perisomatic pyramidal cell compartment are mostly not affected in major depression. NPY, neuropeptide Y; PYR, pyramidal neuron; PV, parvalbumin.