Table 1.

Low somatostatin in human neurological disorders.

Neurological disorders	Brain region	Pathological findings	Reference
Major depressive disorder	CSF	Decreased	Agren and Lundqvist (1984), Kling et al. (1993), Molchan et al. (1993)
	Dorsolateral prefrontal cortex	Decreased (RNA expression)	Sibille et al. (2011)
	Anterior cingulate cortex	Decreased (RNA expression)	Tripp et al. (2011), Tripp et al. (2012)
	Amygdala	Decreased (RNA and protein expression)	Guilloux et al. (2012)
Schizophrenia	CSF	Decreased	Bissette et al. (1986), Reinikainen et al. (1990)
	Dorsolateral prefrontal cortex	Decreased (RNA expression)	Morris et al. (2008), Guillozet-Bongaarts et al. (2013)
	Hippocampus	Decreased (neuron number and density)	Konradi et al. (2011a)
	Caudal entorhinal cortex	Decreased (neuron number and density)	Wang et al. (2011)
	Parasubiculum	Decreased (neuron number and density)	Wang et al. (2011)
Bipolar disorder	Caudal entorhinal cortex	Decreased (neuron density)	Wang et al. (2011)
	Parasubiculum	Decreased (neuron density)	Wang et al. (2011)
	Hippocampus	Decreased (neuron number and RNA expression)	Konradi et al. (2011b)
	Dorsolateral prefrontal cortex	Decreased (RNA expression; trend level)	Sibille et al. (2011)
Alzheimer’s disease	CSF	Decreased	Bissette et al. (1986); Tamminga et al. (1987)
	Temporal cortex	Decreased (immune-reactivity)	Rossor et al. (1980); Candy et al. (1985)
	Frontal cortex	Decreased (immune-reactivity)	Davies and Terry (1981); Candy et al. (1985)
	Hippocampus	Decreased (gene expression per cell)	Dournaud et al. (1994)
	Parahippocampal cortex	Decreased (neuronal density)	Dournaud et al. (1994)
Parkinson’s disease	CSF	Decreased	Dupont et al. (1982)
	Frontal cortex	Decreased (radioimmune-reactivity)	Epelbaum et al. (1988)
Others	Temporal cortex	Decreased (immune-reactivity)	Beal et al. (1986)