Table 1.
miRNAs and their targets.
| miRNA | Target genes | Pathways | Log2Tg-rap/Tg |
|---|---|---|---|
| miR-466i | Gli3, Srgap2, Csrnp3, Lmx1a, Nrf1, Strbp, Csnk1e, Csnk1d | Hedgehog signaling pathway, PDGF signaling pathway, Apoptosis, Cell cycle, Cell communication, Response to stress, Wnt pathway | −0.57 |
| miR-467f | Ppp2r2a, Foxj3, Casp2, Cxcr4 | FGF signaling pathway-PI3 kinase pathway, TGF-beta signaling pathway, Apoptosis signaling pathway cytokine signaling pathway | −0.33 |
| miR-669a | Ptpre, Cdc14a, Ank1, Egr1, Rab6, Ankrd45 | Cell cycle, cell communication, Angiotensin II-stimulated signaling through G proteins and beta-arrestin, Response response to stress | −0.40 |
| miR-497/16 | Atp7a, Zbtb34Prkar2a, Akt3Tlk1Traf3 | Heterotrimeric G-protein signaling pathway, Ras Pathway, Hypoxia response via HIF activation, FAS pathway, p53 pathway feedback loops 2, Cell cycle, cytokine-mediated signaling pathway | 1.79 0.84 |
| miR-140 | Pdgfra, Ppp2r3a, Nlk, Wnt9a, Foxp2, Bcl2l1 | FGF pathway, Angiogenesis, Wnt pathway, Cadherin pathway, Insulin/IGF pathway, TGF-beta pathway, Apoptosis pathway | 1.28 |
| miR-145 | Epb4.1l5, Add3, Yes1, Rasa2, Nras, PPP3CA, PPP3R2, DUSP | PDGF pathway, B cell activation, Cadherin pathway, PDGF pathway, FGF pathway, PI3 kinase pathway, VEGF pathway, Ras Pathway, Wnt pathway, Oxidative pathway | 0.71 |
| miR-331 | Cdh9, ING5 | Wnt signaling pathway, Cadherin signaling pathway | 0.86 |
| miR-30a/c | Cyp24a1, Mkrn3, Celsr3, Klhl20, ppp2r5e, APC | Vitamin D metabolism, EGF, FGF receptor pathway, p53 pathway, PI3 kinase pathway, Cadherin pathway, Apoptosis pathway, TGF-beta pathway, Wnt pathway, Oxidative pathway | 0.45 0.33 |
| miR-22 | Arrb1, Esr1, Clic4, Prkar2a, Styx | Wnt pathway, Angiotensin II-stimulated signaling, cytokine pathway, p53 pathway, Dopamine receptor mediated signaling pathway, Beta1 adrenergic receptor pathway, Oxidative stress response | 0.58 |
| miR-378 | Efna5, Arf2, Dcbld2, Frk, Mapk1 | Integrin pathway, Insulin/IGF pathway, TGF-beta pathway, Interleukin pathway, PI3 kinase pathway, Apoptosis pathway, B cell activation, Angiotensin II-stimulated signaling, Ras Pathway | 0.11 |
| miR-100/99 | MTOR, KBTBD8, TARDBP | PDGF signaling pathway, EGF receptor signaling pathway, Hypoxia response via HIF activation, p53 pathway by glucose deprivation | 0.38 0.56 |
| miR-199 | BCAR3, MAP3K4, CDK17, MTOR | PDGF signaling pathway, EGF receptor signaling pathway, Hypoxia response via HIF activation, p53 pathway by glucose deprivation | 0.37 |
| miR-200a/b/c/429 | ZEB2, ZEB1, DUSP Wnt 16, ABL2, MAP2K4 | Insulin/IGF pathway, FAS signaling pathway, FGF signaling pathway, Oxidative stress response, Integrin signalling pathway, p38 MAPK pathway, EGF receptor signaling pathway, Apoptosis signaling pathway | 0.32 0.73 0.1 0.71 |