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Effect of fucoidan on mitogen-activated protein (MAP) kinase signaling. The levels of phospho-p38 and p38 (A) as well as phospho-ERK1/2 and ERK1/2 (C) were examined by Western blot. Data represent the percentage of phospho-p38 and p38 (B) as well as phospho-ERK1/2 and ERK1/2 (D) levels in PC-3 cells. Data are presented as mean ± SD from three independent experiments. * p < 0.01, ** p < 0.05, and *** p < 0.001 compared with the control (control; without fucoidan).
