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. Author manuscript; available in PMC: 2013 Sep 9.
Published in final edited form as: Cell. 2013 May 9;153(4):785–796. doi: 10.1016/j.cell.2013.04.007

Figure 1. LLOp:I-Ab- and 2W:I-Ab-specific effector cells have consistent patterns of differentiation after Lm infection.

Figure 1

(A) Plot showing identification of CD4+ T cells from the bound fraction after enrichment with p:I-Ab tetramer. (B) CD4+ T cells identified as in (A) from a naive B6 mouse with a gate on CD44low 2W:I-Ab+ (left) or LLOp:I-Ab+ (right) cells. (C) Plots of T-bet and CXCR5 for LLOp:I-Ab-specific cells from a naïve B6 mouse (left) or a B6 mouse 7 days after Lm infection (right). (D) CD4+ T cells identified as in (A) from a B6 mouse 6 days after Lm-2W infection with a gate on CD44high 2W:I-Ab+ (left) or LLOp:I-Ab+ (right) cells. (E) Plots used to identify CXCR5− PD-1− Th1, CXCR5int PD-1− Tfh, and CXCR5high PD-1+ GC-Tfh cells among 2W:I-Ab-specific (left) and LLOp:I-Ab-specific (right) cells identified as in (D), 6 days after Lm infection. (F) Percentage ± SD (n=10) of 2W:I-Ab+ (black bars) and LLOp:I-Ab+ (white bars) CD4+ T cells that were Th1, Tfh, or GC-Tfh cells, 6 days after Lm infection.