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Mutant TGF-β1/Fc fusion protein gene construction. Scheme for the genetic fusion of mutant human TGF-β1 and Fcγ4 cDNAs to create a TGF-β1/Fc immunoligand. Mutations were made in the pro region of TGF-β1 precursor by using site-directed mutagenesis to replace Cys33, Cys223 and Cys225 with Ser residues, which render TGF-β1/Fc immunoligand biologically active.
