Table 4.

Summary of anatomic foci showing brain activity of acupuncture stimulation and positive and negative bold responses associated with the intensity of individual needling sensation (P < 0.05 corrected).

Atlas structure at the center of maximum difference		Mean fMRI response to acupuncture				Pressure				Heaviness
		x	y	z	t*	x	y	z	t*	x	y	z	t*
Straight gyrus	L	−2	29	−10	−4.40	−2	59	−1	−3.64
	R	5	11	−10	−4.65
Superior frontal gyrus	L					−5	50	27	−3.19	−5	−14	48	2.94
	R	8	32	48	5.01
	R	8	53	24	−4.19
Orbital gyri	R	11	44	−13	−4.97	35	29	−7	−3.78	35	29	−7	4.52
Orbital sulci	R	17	41	−10	−3.71	32	29	−7	−3.45	38	32	−4	4.33
Anterior cingulate cortex	L	−8	32	−4	−3.17	−5	32	3	−3.08	−5	41	3	3.70
	R	8	32	−7	−5.01	8	38	3	−3.29	8	44	3	3.84
Subcallosal gyrus	L	−2	11	−7	−3.94	−2	14	3	−2.77
	R	5	11	−10	−4.65
Middle-anterior cingulate cortex	R
Postcentral gyrus	R	44	−20	51	−3.40
Postcentral sulcus	L	−47	−32	36	3.85
Superior parietal lobule	L	−11	−65	51	−3.28
	R	20	−74	39	−3.26
Intraparietal sulcus	L					−35	−59	39	2.90	−38	−56	39	−4.08
	R									29	−53	42	−4.07
Angular gyrus	L					−53	−59	30	−3.44
	R	44	−71	30	−3.25	44	−65	33	−2.72
Supramarginal gyrus	L	−62	−32	33	4.14
	R	56	−23	24	3.10
Precuneus	L	−8	−62	48	−3.69					−5	−59	33	2.81
	R	5	−62	42	−3.34
Ant. insula	L	−26	26	6	2.85
	R	29	17	−10	−3.73	29	17	−10	−3.34	29	23	−7	3.57
Sup. insula	L	−26	20	15	4.16
	R	35	26	15	2.82	29	23	12	2.95
Superior temporal gyrus	R	53	8	−13	−4.92	47	17	−10	−3.23
Superior temporal sulcus	R	53	−17	−10	−4.94	56	−2	−16	−3.80	50	−2	−10	3.41
Middle temporal gyrus	L	−62	−26	−7	−3.04	−62	−41	3	−4.16
	R	56	2	−16	−5.19	59	−2	−19	−5.25	62	−17	−13	3.48
Hippocampus	L	−29	−23	−7	−2.72	−23	−41	−1	−3.50
	R	23	−11	−16	−3.37	32	−35	−4	−4.45	32	−35	−4	2.87
Amygdala	R	26	−8	−16	−3.27
Parahippocampal gyrus	L	−11	−38	−7	−4.09	−23	5	−19	−4.86
	R	23	2	−25	−3.98	20	5	−22	−3.46
Lingual gyrus	L	−8	−62	−1	−4.21	−5	−80	−13	−3.95
	R	14	−47	−7	−3.65	11	−50	−4	−3.32
Temporal pole	R	32	17	−28	−5.17	23	5	−28	−3.74
Cuneus	L	−5	−83	12	−3.64
	R	5	−86	12	−2.79
Thalamus proper	L	−17	−20	18	3.09
	R
Corpus callosum	L	−12	−42	19	3.09
	R
Cerebellum cortex	L	−35	−68	−25	4.48					−8	−53	−31	2.72
	L	−11	−38	−10	−3.93	−38	−56	−25	−3.01
	R	29	−44	−43	3.83
	R	5	−41	−10	−3.48	41	−68	−34	−4.36
Brain stem		5	−26	−34	−3.00
Atlas structure at the center of maximum difference		Fullness				Numbness				Tingling
		x	y	z	t*	x	y	z	t*	x	y	z	t*
Straight gyrus	L									−2	53	−7	−3.54
	R
Superior frontal gyrus	L	−14	56	27	−2.88					−20	8	60	−3.73
	R					8	−2	57	3.69
	R									17	44	39	−2.93
Orbital gyri	R	29	26	−10	−3.48					38	50	−1	−3.83
Orbital sulci	R	32	29	−7	−2.99
Anterior cingulate cortex	L
	R	11	41	−1	−4.20
Subcallosal gyrus	L
	R
Middle-anterior cingulate cortex	R					5	8	30	3.61
Postcentral gyrus	R									47	−29	54	−3.46
Postcentral sulcus	L					−56	−23	30	3.10
Superior parietal lobule	L					−23	−71	36	2.98
	R	20	−68	42	2.61	20	−68	48	2.96	20	−68	45	−3.38
Intraparietal sulcus	L					−20	−68	39	3.19	−44	−47	39	−3.40
	R	29	−50	39	3.71	32	−56	39	4.47	32	−65	39	−2.79
Angular gyrus	L					−29	−68	36	2.65	−44	−56	42	−3.66
	R	56	−44	27	−2.95	35	−65	39	3.55	38	−65	42	−3.37
Supramarginal gyrus	L					−62	−29	36	3.67	−44	−47	42	−2.96
	R	50	−23	18	3.31	56	−23	30	3.00
Precuneus	L									−14	−47	57	−2.69
	R
Ant. insula	L
	R	29	23	−7	−2.91
Sup. insula	L
	R					35	26	15	3.03
Superior temporal gyrus	R
Superior temporal sulcus	R	47	−2	−19	−2.62	53	−14	−10	−2.85	44	−71	24	−2.59
Middle temporal gyrus	L									−62	−32	−4	−2.79
	R	62	−17	−16	−3.16	56	2	−16	−4.02
Hippocampus	L					−20	−32	−7	−3.92	−17	−29	−7	4.69
	R					35	−32	−7	−2.56	35	−26	−7	2.90
Amygdala	R
Parahippocampal gyrus	L					−14	−38	−7	−3.65	−14	−32	−7	3.87
	R
Lingual gyrus	L					−11	−86	−7	2.50
	R
Temporal pole	R
Cuneus	L					−5	−86	12	2.79
	R
Thalamus proper	L					−20	−32	−4	−3.90	−8	−32	6	5.48
	R									11	−29	15	3.56
Corpus callosum	L									−17	−35	24	5.17
	R									8	−35	18	4.70
Cerebellum cortex	L	−2	−44	−19	2.50	−47	−56	−28	3.55	−38	−71	−31	3.89
	L					−14	−38	−13	−2.75
	R	2	−44	−19	3.12					44	−41	−40	4.00
	R					35	−56	−40	3.14
Brain stem						8	−29	−34	4.02	−14	−23	−7	3.76

t* is the value taken from the voxel with maximal signal change.

“−” means negative bold responses.

Ant. insula: anterior segment of the circular sulcus of the insula.

Sup. insula: superior segment of the circular sulcus of the insula.