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. Author manuscript; available in PMC: 2013 Sep 9.
Published in final edited form as: Dev Neurosci. 2012 May 8;34(0):198–209. doi: 10.1159/000337229

Fig. 1.

Fig. 1

Overt phenotype of homozygous NEX-Pten mice. a Survival curve in a cohort of homozygous (Hom), heterozygous (Het) and wild type (WT) NEX-Pten littermates. Homozygous NEX-Pten knockout mice die prematurely, mostly within the first postnatal week. The survival curve for homozygous NEX-Pten mutant mice is significantly different than that of wild type or heterozygous mice (p<0.0001). b Body weight plot from a NEX-Pten littermate cohort. The average body weight of homozygous NEX-Pten mice is significantly less than wild type littermates at postnatal day (P) 3 (p<0.04) and P6 (p<0.001). c A rare homozygous NEX-Pten mouse that survived to P8 appears runted compared to a wild type littermate. d Images of the whole brain from P8 littermates reveal megalencephaly in the homozygous mutant. e Treatment of homozygous NEX-Pten mice with rapamycin (Rapa) significantly prolongs their survival compared untreated mutants (p<0.001). f Rapamycin treatment also significantly increases body weight at several postnatal days(p<0.05).