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. Author manuscript; available in PMC: 2013 Sep 9.
Published in final edited form as: Dev Neurosci. 2012 May 8;34(0):198–209. doi: 10.1159/000337229

Fig. 5.

Fig. 5

Upregulation of the PI3K/Akt/mTOR signaling pathway in the forebrain of newborn homozygous NEX-Pten mice. a Representative Western blots of Pten, phospho- Akt serine 473 (p-Akt Ser473), phospho- Akt threonine 389 (p-Akt Thr389) and total Akt in NEX-Pten littermates of the indicated genotypes. b Representative Western blots of Pten, phospho-ribosomal protein S6 (Serine 240/244) (p-S6), Grb10 and actin in NEX-Pten littermates of the indicated genotypes. Loss of Pten in homozygous mutant mice correlates with the increased phosphorylation of Aktand mTOR targets. Images are representative of data obtained from 3–6 animals per genotype.