. Author manuscript; available in PMC: 2013 Sep 9.

Published in final edited form as: Psychiatr Genet. 2012 Jun;22(3):123–129. doi: 10.1097/YPG.0b013e328353956a

Table 2.

Linkage analyses of panic-related phenotypes: maximum lod scores

Phenotype Category	Phenotype	Current study sample size		Current Study: Maximum Lod³
Phenotype Category	Phenotype	Number of Families	Individuals Genotyped (Affected/All)	Chrom	Marker (cM)	Model	Lod Score¹
Composite PD-related phenotypes based on previous scans²	Broad anxiety (PD, GAD, Soc, Spec, somatoform)	120	869/992	2	D2S125 (261)	Dominant Sex-dif, Hetlod	2.64
	PD or phobias (PD, specific social, or agoraphobia) ³	120	861/992	2	D2S125 (261)	Dominant Sex-dif, Hetlod	2.52
	Early comorbid anxiety (PD & anxiety disorder <13 years)	120	247992	2	D2S1788 (56)	Recessive Sex dif, Hetlod	1.96
Panic Disorder Subtypes	PD no Agoraphobia	112	379/916	16	N/A (141)	Dominant MP, Hetlod	2.76^†
	PD with Agoraphobia	92	271/824	7	D7S821 (109)	Recessive Sex-dif, Hetlod	2.67
	Early onset PD (≤20)	91	213/767	4	D4S2361 (93)	Dominant 2 point, Hetlod	2.29
	Early onset PD (≤13)	51	81/734	20	D20S480 (80)	Recessive 2point, Homlod	2.69^†
Anxiety Disorders Segregating in PD pedigrees	Specific Phobia	69	247/644	13	D13S793 (76)	Recessive 2point, Homlod	2.77^*^#
	Social Phobia	61	213/609	7	D7S1799 (114)	Dominant 2pint, Hetlod	2.28
	Specific or Social Phobia	93	386/816	13	D13S793 (76)	Recessive 2point, Homlod	4.27^**^Ψ

Significance: Model specific p values (see text, data analysis)

^†

p=0.1;

p≤.05;

^**

p≤.01.

“Global” p values:

^Ψ

p=.076;

p=0.9

Modified respectively from Thorgeirsson et al, 2004; Kaabi et al, 2006; and Smoller et al, 2001.

Abbreviations: Chrom = chromosome; cM=centimorgans, Hetlod = lod calculated under assumption of heterogeneity; Homlod = lod calculated under assumption of homogeneity; MP= multipoint, N/A = not apply; sex-dif = calculated will allowance for gender distinction in recombination fraction.