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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Cancer Res. 2013 Jul 9;73(17):5347–5359. doi: 10.1158/0008-5472.CAN-13-0087

Figure 1. Tumor stroma incorporation is diminished in CD44-/- mice compared to controls.

Figure 1

(A) EO771 tumor burdened CD44-/- mice survived significantly longer (p<0.05) than WT mice. Mice were euthanized due to increased burden of primary tumor in accordance with institutional standards. (B) Incorporation of host stroma into the EO771 tumors was significantly less (p<0.01) in tumors engrafted in CD44-/- (β-gal+) mice than in tumors engrafted in WT (RFP+) mice. Stroma % was measured based on the averaged accumulation of αSMA, FAP and FSP expression in both tumor models based on the immunofluorescent score algorithm using Nuance software. (C) H&E tumor section from CD44-/- mice shows that stromal cells were evenly dispersed with tumor cells whereas stromal cells formed clusters of linear structural patterns in WT mice.