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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Cancer Res. 2013 Jul 9;73(17):5347–5359. doi: 10.1158/0008-5472.CAN-13-0087

Figure 4. CD44-knockdown of human MSC decreases efficacy as tumor associated fibroblasts.

Figure 4

(A) Long-term (21 day) tumor-conditioned shCD44 MSC did not express FAP, FSP or CD44 and expressed diminished levels of α-SMA, PDGFRβ, TSP and Twist and were deficient in vimentin cleavage products when compared to the conditioned shNS MSC. (B) shCD44 MSC were deficient in migration toward TCM compared to shNS MSC. Hyaluronan oligomer (oHa) was used as a CD44 inhibition control on shNS MSC.