Table 2. MCAR Example: Results from a hypothetical clinical trial evaluating the effect of treatment on improvement in body fat (Outcome).
a. Results from the whole study population. | ||||
Outcome
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Treatment | Y | N | ||
• Risk Ratio=(30/40)/(20/40)=1.5 | ||||
A | 30 | 10 | 40 | • SE(Ln(RR))=0.18 |
B | 20 | 20 | 40 | • 95% CI =1.05,2.15 |
50 | 30 | 80 | • Chi-Square=5.33 P=0.02 | |
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b. Results from completers following 30% missing data from a
Missing Completely At Random Mechanism (MCAR)*.
| ||||
Outcome
|
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Treatment | Y | N | ||
• Risk Ratio=(21/28)/(14/28)=1.5 | ||||
A | 21 | 7 | 28 | • SE(Ln(RR))=0.22 |
B | 14 | 14 | 28 | • 95% CI =0.98,2.30 |
35 | 21 | 56 | • Chi-Square=3.73 P=0.053 |
*Each cell from Table 2a is multiplied by 70% to obtain 30% missing data from an MCAR mechanism in Table 2b.