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. Author manuscript; available in PMC: 2014 Mar 5.
Published in final edited form as: Nature. 2013 Aug 28;501(7465):58–62. doi: 10.1038/nature12504

Figure 2. Lentiviral shRNA knockdown of Top1 or Top2b in mouse cortical neurons reduces expression of long genes.

Figure 2

a, b, Representative western blots and quantification of TOP1 and TOP2B seven days post infection. Normalized to β-actin in arbitrary units (A.U.). **P<0.01 relative to scrambled (Scr) control, Student’s t-test. Error bars, s.e.m. n=3 biological replicates. c, d, Gene expression from Affymetrix microarrays, relative to scrambled control shRNA. Plotted as mean expression change in bins of 200 genes by length.