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. Author manuscript; available in PMC: 2014 Mar 5.
Published in final edited form as: Nature. 2013 Aug 28;501(7465):58–62. doi: 10.1038/nature12504

Figure 3. Topotecan impairs transcription elongation of long genes.

Figure 3

a, Mouse cortical neurons treated with vehicle or topotecan (300 nM for 3 days). Pol II density in gene bodies and promoter regions, averaged for bins of 200 genes by length. b, c, Change in Pol II density across genes and (c) across the first 10 kb, averaged for groups of 200 genes by length. Gene bins aligned relative to the transcription start site (TSS). d, Mouse cortical neurons treated with 100 μM DRB for 3 days. Affymetrix microarray expression compared to controls in bins of 200 genes by length.