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. Author manuscript; available in PMC: 2013 Sep 9.
Published in final edited form as: Sci Transl Med. 2011 Jun 15;3(87):87ra52. doi: 10.1126/scitranslmed.3002270

Fig. 2.

Fig. 2

Surgical castration (SCx) restored the survival of cardiac allografts in aged mice treated with anti-CD45RB. Hearts from C3H donors were transplanted into the abdominal cavity of 12-month-old mice, some of which had undergone surgical castration 1 month before cardiac transplantation. Recipients were then treated with or without anti-CD45RB antibody. Although graft survival was significantly prolonged in the anti-CD45RB–treated, noncastrated 12-month-old mice compared with untreated mice (P < 0.001), no grafts permanently survived in the former. However, surgical castration significantly improved long-term graft survival in old mice treated with anti-CD45RB compared with normal 12-month-old mice treated with anti-CD45RB (P < 0.0001).