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. Author manuscript; available in PMC: 2013 Sep 9.
Published in final edited form as: Sci Transl Med. 2011 Jun 15;3(87):87ra52. doi: 10.1126/scitranslmed.3002270

Fig. 3.

Fig. 3

Chemical castration (CCx) restored the survival of cardiac allografts in older mice treated with anti-CD45RB. One month before transplantation, mice at 8, 11, or 13 months were injected with a 1-month Lupron Depot; an additional dose was given on the day of transplantation. (A) In mice at age of 12 months, the anti-CD45RB–treated control mice rapidly rejected their grafts. Injection of Lupron Depot enhanced the efficacy of anti-CD45RB, leading to long-term graft acceptance in more than 30% of animals (P < 0.003). (B) In mice at age of 14 months, Lupron Depot improved the long-term graft survival in 50% of anti-CD45RB–treated mice compared with no graft acceptance in control mice (P < 0.02). (C) In 9-month-old mice, 50% of control mice demonstrated long-term tolerance and 100% of Lupron Depot–treated mice demonstrated long-term tolerance (P < 0.04).