Table 1.
Asthma trials combined for heritability analysis. Sample size is given per-phenotype, per-trial. Samples sizes are post-quality control. Genotyping for the LOCCS, LODO, and Sepracor studies was performed at Riken (Kanagawa, Japan) on Infinium HD Human610-Quad BeadChip chips (Illumina). Genotyping for CAMP was performed at the Channing Division of Network Medicine (Boston, MA) on Infinium Human610 and HumanHap550 BeadChip (Illumina). Genotyping of ACRN and CARE on Affymetrix 1M human hap chips was performed by Affymetrix Inc. (Santa Clara, CA). Quality control was performed at the Channing. Imputation for the BDR cohort was done vs. the 1000 Genomes Project (June 2010) using the Markov Chain Haplotyping (MaCH) software program.20
| Trial | Full Name | Criteria | Genotyping | Cohort (n) | Reference |
|---|---|---|---|---|---|
| ACRN | Asthma Clinical Research Network | Adult | Affymetrix 6.0, Affymetrix. | BDR (217) AHR (355) | Denlinger LC, Sorkness CA, Chinchilli VM, Lemanske RF, Jr. Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network and Childhood Asthma Research and Education Network. J Allergy Clin Immunol 2007;119:3–11; quiz 2–3. |
| CAMP | Childhood Asthma Management Program | Children, 5–12 yr old. | Illumina HumanHap550v3 or Infinium HD Human610-Quad BeadChip, Channing. | BDR (521) AHR (513) Asthma (581) | The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Childhood Asthma Management Program Research Group. Control Clin Trials 1999;20:91–120. |
| CARE | Childhood Asthma Research and Education Network | Children, 2–17 yr old. | Affymetrix 6.0, Affymetrix. | BDR (166) AHR (186) | Guilbert TW, Morgan WJ, Krawiec M, et al. The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network. Control Clin Trials 2004;25:286–310. |
| LOCCS | Leukotriene Modifier or Corticosteroid or Corticosteroid-Salmeterol Trial | Adult | Illumina Infinium HD Human610-Quad BeadChip, RIKEN. | BDR (114) Asthma (132) | Peters SP, Anthonisen N, Castro M, et al. Randomized comparison of strategies for reducing treatment in mild persistent asthma. N Engl J Med 2007;356:2027–39. |
| LODO | Effectiveness of Low Dose Theophylline as an Add-on Treatment in Asthma | Adult | BDR (105) Asthma (121) | American Lung Association Asthma Clinical Research Centers. Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma. Am J Respir Crit Care Med 2007;175:235–42. | |
| Sepracor | Sepracor | BDR > 15%, Adult | BDR (375) Asthma (432) | Baron RM, Palmer LJ, Tantisira K, et al. DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma. American journal of respiratory and critical care medicine 2002;166:927–32. | |
| Illumina | Illumina Controls | Illumina HumanHap550v3, Illumina. | Asthma (1367) | Illumina Inc, San Diego, CA |