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. Author manuscript; available in PMC: 2013 Sep 9.
Published in final edited form as: Nat Cell Biol. 2012 Oct 21;14(11):1159–1168. doi: 10.1038/ncb2597

Figure 7. Pericentrin-like protein forms elongated fibrils that extend radially from the centriole wall to support the 3D organization of the PCM.

Figure 7

During centrosome maturation, the PCM is organized in two distinct structural domains: a layer juxtaposed to the centriole wall, and proteins extending further away from the centriole organized in a matrix. In this proximal PCM domain, we found elongated Plp fibrils that are anchored with the PACT domain to the centriole wall and with their N-terminus extending outwards. Plp is exclusively associated with mother centrioles until metaphase and form a gap where daughter centriole assembles. During centrosome maturation, Plp facilitates the proper 3D assembly of the PCM distal layer by organizing a shell of Cnn molecules that is in place around the wall of mother centrioles from the interphase cell cycle stage.