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. Author manuscript; available in PMC: 2013 Sep 9.
Published in final edited form as: Annu Rev Biochem. 2012 Apr 13;81:687–714. doi: 10.1146/annurev-biochem-061009-102430

Figure 2.

Figure 2

Models of lipid droplet (LD) formation and expansion. For formation, the budding model is shown, with the LD either remaining attached to the endoplasmic reticulum (ER) or detached. The neutral lipid synthesis enzymes, ACAT or DGAT, catalyze the formation of lipids that fill the core. For lipid droplet expansion, the models of local synthesis of triacylglycerol (TG) at the LD and of LD fusion (coalescence) are shown. Abbreviations: DAG, diacylglycerol; FA-CoA, fatty acyl-coenzyme A; SE, sterol ester; PC, phosphatidylcholine.