Figure 11.

Protracted pulmonary pathology and example of glomerular SPION microbubbles. (A) Macrophages engulfing SPION microbubbles in a mural intravascular thrombus associated with neutrophils in the lung of one rat 24 hours post injection and (B) localized chronic inflammation characterized by accumulated macrophages, fewer neutrophils, and marked fibrosis in the lung of a rat, 4 weeks post injection of SPION microbubbles. (C) Renal cortex showing occasional SPION microbubbles in the glomerular vascular tuft. Size bars represent 50, 10, and 10 μm, respectively.

Abbreviation: SPION, superparamagnetic iron oxide.