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. 2013 Aug 19;110(36):E3388–E3397. doi: 10.1073/pnas.1305275110

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Fig. 5. — HSF2 interacts with mitotic chromatin. (A) Gene ontology analyses of HSF1 and HSF2 target loci in mitosis. The genomic regions were defined as in Fig. 4. (B) The number of HSF1 (red) and HSF2 (green) target loci in cycling and mitotic heat-treated cells. (C) HSF1 and HSF2 protein levels in scrambled-transfected (Scr), HSF1-depleted (shHSF1), and HSF2-depleted (shHSF2) mitotic cells during heat stress. (D) Histograms of scrambled-transfected (Scr), HSF1-depleted (shHSF1), and HSF2-depleted (shHSF2) mitotic cells after a 1-h heat treatment, indicating that neither transfection nor lack of HSF1 or HSF2 compromises the synchronization of cells to G2/M. (E) mRNA levels of HSPH1, HSPH2, NUDC, and MLL in mitotic cells with or without HSF1 or HSF2. mRNA levels and statistical significances were analyzed as in Fig. 2.