Table 1.
HSF1 and HSF2 occupancy on HSPA, HSPB, HSPC, HSPH, and chaperonin genes
| Family | Gene | Alias | HSF1 |
HSF2 |
Binding site | Paused RNPII* | ||||||
| Cycling |
Mitosis |
Cycling |
Mitosis |
|||||||||
| C | HS | C | HS | C | HS | C | HS | |||||
| HSPA | HSPA1A | HSP70-1 | 2.8 | 40.4 | 2.5 | 16.3 | 5.2 | 25.6 | 3.3 | 10.8 | Promoter | Yes |
| HSPA1B | HSP70-2 | 4.3 | 45.1 | 5.3 | 20.5 | 5.4 | 26.8 | 5.4 | 15.5 | Promoter | Yes | |
| HSPA1L | HSP70-1L | 2.8 | 40.4 | 2.5 | 16.3 | 5.2 | 25.6 | 3.3 | 10.8 | Promoter | Yes | |
| HSPA2 | HSPA3 | — | — | — | — | — | — | — | — | — | No | |
| HSPA5 | BIP, GRP78 | — | — | — | — | — | — | — | — | — | Yes | |
| HSPA6 | HSP70B' | — | 15.2 | — | — | — | 7.3 | — | — | Promoter | Yes | |
| HSPA7 | HSP70 | — | 3.0 | — | — | — | — | — | — | Promoter | No | |
| HSPA8 | HSC70 | 4.3 | 29.5 | 2.8 | 5.3 | 20.2 | 26.8 | 8.3 | 12.3 | Promoter | Yes | |
| HSPA9 | GRP75 | — | 6.6 | — | — | — | 5.9 | — | — | Promoter | Yes | |
| HSPA12A | FLJ13874 | — | — | — | — | — | — | — | — | — | No | |
| HSPA12B | RP23-32L15.1 | — | — | — | — | — | — | — | — | — | No | |
| HSPA13 | Stch | — | — | — | — | — | — | — | — | — | Yes | |
| HSPA14 | HSP70-4 | — | — | — | — | — | — | — | — | — | Yes | |
| HSPB | HSPB1 | HSP27-1 | — | 23.8 | — | 6.3 | — | 16.5 | 3.5 | 5.6 | Promoter | Yes |
| HSPB2 | HSP27-2 | — | 14.1 | — | — | — | 10.4 | — | — | Promoter | No | |
| HSPB3 | HSPL27 | — | — | — | — | — | — | — | — | — | No | |
| HSPB4 | CRYAA | — | — | — | — | — | — | — | — | — | No | |
| HSPB5 | CRYAB | — | 14.1 | — | — | — | 10.4 | — | — | Promoter | No | |
| HSPB6 | HSP20 | — | — | — | — | — | — | — | — | — | No | |
| HSPB7 | cvHSP | — | — | — | — | — | — | — | — | — | No | |
| HSPB8 | HSP22 | — | — | — | — | — | — | — | — | — | No | |
| HSPB9 | FLJ27437 | — | 12.3 | — | 3.5 | 7.0 | 19.0 | — | 6.0 | Promoter | No | |
| HSPB10 | ODF1 | — | — | — | — | — | — | — | — | — | NA | |
| HSPB11 | HSP16.2 | — | — | — | — | — | — | 3.1 | — | Promoter | Yes | |
| HSPC | HSPC1 | HSP90AA1 | — | 13.2 | — | 6.0 | — | 10.5 | 3.2 | 5.3 | Promoter | Yes |
| HSPC2 | HSP90AA2 | — | — | — | — | — | — | — | — | — | NA | |
| HSPC3 | HSP90AB1 | — | 23.8 | — | 8.2 | 6.8 | 14.1 | — | 9.9 | Promoter | Yes | |
| HSPC4 | HSP90B1 | — | — | — | — | — | — | — | — | — | Yes | |
| HSPC5 | TRAP1, HSP90L | — | — | — | — | — | — | — | — | — | Yes | |
| HSPD | HSPD1 | HSP60, GROEL | 5.8 | 43.0 | 3.5 | 15.1 | 17.8 | 33.4 | 6.0 | 9.5 | Promoter | Yes |
| HSPE | HSPE1 | HSP10, GROES | 5.8 | 43.0 | 3.5 | 15.1 | 17.8 | 33.4 | 6.0 | 9.5 | Promoter | Yes |
| HSPH | HSPH1 | HSP105/110 | — | 32.6 | — | 8.8 | — | 19.0 | — | 6.3 | Promoter | Yes |
| HSPH2 | HSPA4 | — | 22.5 | — | 4.2 | — | 20.9 | — | 4.2 | Promoter | Yes | |
| HSPH3 | HSPA4L | — | 9.1 | — | 4.2 | — | 5.5 | — | 3.5 | Promoter | Yes | |
| HSPH4 | HYOU1 | — | — | — | — | — | — | — | — | — | Yes | |
| TRiC | CCT1 | TCP1, CCTA | 3.5 | 31.8 | — | 4.6 | 8.5 | 21.5 | — | 5.2 | Promoter | Yes |
| CCT2 | CCTB | — | 8.7 | — | — | — | 6.3 | — | — | Prom/Int | Yes | |
| CCT3 | CCTG | — | 8.5 | — | — | — | 8.5 | 3.9 | — | Prom/Int | Yes | |
| CCT4 | CCTD | — | 12.4 | — | 3.9 | 4.7 | 8.5 | — | — | Promoter | Yes | |
| CCT5 | CCTE | — | 14.0 | — | 2.7 | — | 15.3 | — | 4.9 | Promoter | Yes | |
| CCT6A | CCTZ | — | — | — | — | — | 5.7 | — | — | Promoter | Yes | |
| CCT6B | CCTZ2 | — | — | — | — | — | — | — | — | — | Yes | |
| CCT7 | CCTH | — | 12.5 | — | 3.5 | — | 11.4 | — | 3.9 | Promoter | Yes | |
| CCT8 | CCTQ | — | 5.0 | — | — | — | 7.1 | — | — | Promoter | Yes | |
Fold enrichments ≥2 are shown. The nomenclature of HSPs is according to ref. 85. C, control; HS, heat shock; NA, not analyzed; Prom/Int, promoter or intron depending on the transcript variant.
*The RNPII density signal is recovered from ENCODE (wgEncodeEH000616; Snyder Laboratory, Yale University).