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. 2013 Aug 22;110(36):14682–14687. doi: 10.1073/pnas.1302759110

Fig. 6.

Fig. 6.

Tet3 overexpression disrupts mOSN axonal targeting. (A) Boxplots of rRNA-depleted RNA log2(FPKM + 1) values of olfactory receptors (ORs) and axon guidance molecules (defined in Materials and Methods) in control and Tet3-tg mOSNs. P values from Wilcoxon two-sided rank-sum test. (B) Immunofluorescent staining of Olfr1507 demonstrating mutually exclusive expression with Tet3-tg. (C) Quantification of GFP intensities within GFP-, Olfr6-, Olfr151-, and Olfr1507-positive OSNs in OMP-tTA/tetO-Tet3-GFP MOEs. (D) Square-root mean 5hmC RPM of ORs and axon guidance molecules with a log2(FPKM + 1) ≥ 2 in either genotype. P values from Wilcoxon two-sided rank-sum test. (E) Analysis of OSN axon targeting to the olfactory bulb in Olfr151-Cre/Tomato-floxed animals under control Tet3 expression (Upper) or Tet3 overexpression in mOSNs (Lower).