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. 2013 Aug 19;110(36):14676–14681. doi: 10.1073/pnas.1313198110

Fig. 4.

Fig. 4.

NAF-1 or mNT are required to support tumor growth. Breast cancer cells (MDA-231) with or without suppressed expression of mNT (mNT−) or NAF-1 (NAF-1−) were injected s.c. into the back of female CD1 nude mice, and tumor growth was monitored over time. (A) Slower tumor growth of breast cancer cells (MDA-231) with suppressed expression of mNT (mNT−) or NAF-1 (NAF-1−) compared with control MDA-231 cells. (B) Reduction of mean tumor volume expressed as percentage of control MDA-231 in mNT− or NAF-1− MDA-231 cells. (C and D) Images of representative tumors of each group obtained at the end of the experiment. (E) Histological analyses of tumors using H&E staining showing large necrotic areas in tumors formed from the control MDA-231 cells compared with tumors formed from mNT− or NAF-1− MDA-231 cells. *P < 0.05.