Table 4.
The effect of three-month supplementation with folic acid on Hcy, blood lipids and apolipoproteins concentrations depending on dyslipidaemia (n=43), BMI ≥25 kg/m2 (n=19) and smoking (n=24) in females.
| Parameter in females | Dyslipidaemia (n=43) | BMI ≥25 kg/m2 (n=19) | Smokers (n=24) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Before | After | p | Before | After | p | Before | After | p | |
| FA (ng/dL) | 6.2 | 12.0 | 0.001 | 8.0 | 13.8 | 0.001 | 7.1 | 12.4 | 0.001 |
| Hcy (μmol/L) | 10.6 | 8.4 | 0.001 | 10.2 | 8.0 | 0.001 | 10.9 | 8.6 | 0.001 |
| T.Ch. (mg/dL) | 218.2 | 204.5 | 0.001 | 201.9 | 191.7 | 0.004 | 201.5 | 193.9 | 0.014 |
| LDL-C (mg/dL) | 118.2 | 107.7 | 0.001 | 110.2 | 101.8 | 0.002 | 108.8 | 102.5 | 0.009 |
| HDL-C (mg/dL) | 60.2 | 59.6 | NS | 54.4 | 54.7 | NS | 56.7 | 57.0 | NS |
| T.Ch./HDL-C | 3.79 | 3.59 | 0.001 | 3.82 | 3.58 | 0.003 | 3.67 | 3.52 | 0.036 |
| LDL-C/HDL-C | 2.1 | 1.93 | 0.001 | 2.1 | 1.92 | 0.002 | 2.02 | 1.9 | 0.031 |
| TG (mg/dL) | 95.2 | 93.4 | NS | 96.4 | 94.5 | NS | 91.7 | 83.1 | NS |
| apoB (mg/dL) | 97.1 | 95.6 | NS | 95.2 | 97.2 | NS | 95.2 | 96.0 | NS |
| apoAI (mg/dL) | 155.7 | 156.4 | NS | 151.9 | 150.7 | NS | 154.3 | 157.6 | 0.032 |
| apoB/apoAI | 0.63 | 0.62 | NS | 0.63 | 0.65 | NS | 0.63 | 0.62 | NS |
| Lp(a) (mg/dL) | 34.1 | 35.3 | NS | 34.2 | 33.4 | NS | 32.3 | 32.7 | NS |
p – evaluated with Student’s paired t-test; FA – folic acid; Hcy – homocysteine; T.Ch. – total cholesterol; LDL-C – low-density lipoprotein cholesterol; HDL-C – high-density lipoprotein cholesterol; TG – triglycerides; apoB – apolipoprotein B; apoAI – apolipoprotein AI; Lp(a) – lipoprotein(a).