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. 2013 Sep 9;8(9):e74008. doi: 10.1371/journal.pone.0074008

Figure 6. Piperlongumine induces Drp1-dependent mitochondrial fission and apoptosis in CDDP-resistant ovarian cancer cells.

Figure 6

(A) Piperlongumine but not CDDP (0–10 µM) down-regulates phospho-Drp1 (Ser637) content. (B) (i) Effect of mDivi-1 (0–10 µM) on piperlongumine-induced mitochondrial fission and (ii) apoptosis, as assessed by Annexin V assay (**, p<0.01; ***, p<0.001 versus respective DMSO control treated with identical mDivi-1 concentration, #, p<0.05; ##, p<0.01; ###, p<0.001 versus respective PL or CDDP treatment in the absence of mDivi-1).).