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. 2013 Sep 9;8(9):e73940. doi: 10.1371/journal.pone.0073940

Figure 1. DCLK1 is essential for human pancreatic tumor xenograft growth.

Figure 1

A, AsPC-1 human pancreatic cancer cells were subcutaneously injected into the flanks of NOD/SCID mice to generate tumors. At day 30, PLGA NP encapsulated siRNAs (siDCLK1 and siSCR) were injected directly into the tumors and followed by injections every third day. After 5 injections, tumors were excised at day 45 and are represented above. Tumor volume was measured every 3 days. B, Representative photograph of mice bearing the tumors from each group are shown. C, The expression of DCLK1 mRNA in the tumors quantitated by real-time RT-PCR. Values are given as average ± SEM, and asterisks denote statistically significant differences (*p < 0.01) compared with Control (NP alone).