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. 2013 Sep 9;8(9):e73940. doi: 10.1371/journal.pone.0073940

Figure 4. DCLK1 regulates LIN28B via let-7a.

Figure 4

A, siRNA-mediated knockdown of DCLK1 in tumor xenografts results in increased expression of pri-let-7a miRNA. B, Following the knockdown of DCLK1, a decrease in miR-let7a dependent luciferase activity was observed in AsPC-1 cells. C, LIN28B mRNA downstream target of let-7a was downregulated in tumors treated with NPsiDCLK1. Values in the bar graphs are given as average ± SEM, and asterisks denote statistically significant differences (*P < 0.01) compared with Control (NP alone).