Table 1. List of peptides resembling the extramembranous regions of bR.

name	Sequence
N-terminus	Acetyl-QAQITGRPEW-Ttds-Lys(Biotin)NH2
loop AB	Biotin-Ttds-KGMGVSDPDAKKFY-NH2
loop AB cyclic	Biotin-Ttds-CKGMGVSDPDAKKFYC-NH2
loop BC	Biotin-Ttsd-GYGLTMVPFGGEQNPI-NH2
loop BC cyclic	Biotin-Ttsd-CGYGLTMVPFGGEQNPIC-NH2
loop CD	Biotin-Ttds-LALLVDADQGT-NH2
loop CD cyclic	Biotin-Ttds-CLALLVDADQGTC-NH2
loop DE	Biotin-Ttds-TKVYSYR-NH2
loop DE cyclic	Biotin-Ttds-CTKVYSYRC-NH2
loop EF	Biotin-Ttds-GFTSKAESMRPEVASTFK-NH2
loop EF cyclic	Biotin-Ttds-CGFTSKAESMRPEVASTFKC-NH2
loop FG	Biotin-Ttds-GSEGAGIVPLNI-NH2
loop FG cyclic	Biotin-Ttds-CGSEGAGIVPLNIC-NH2
C-terminus	Biotin-Ttds-LRSRAIFGEAEAPEPSAGDGAAATS-NH2

Peptides were biotinylated to allow capturing on streptavidin coated plates. Ttds ((N-(3-{2-[2-(3-Amino-propoxy)-ethoxy]-ethoxy}-propyl)-succinamic acid) was used as spacer between the biotin and the peptide to reduce steric hindrance. All peptides were C-terminally amidated.