Table 2. Minimum bactericidal concentration (MBC50 and MBC90) values of selected antimicrobial agents when used alone and in the presence of 8 µg/ml of α-MSH against clinical MRSA strain.
Antibiotic | MBC50/MBC90 (µg/ml) ofantibiotic alone | MBC50/MBC90 (µg/ml) of antibioticin the presence of α-MSH | Fold reduction in MBC values(MBC50/MBC90) of antibiotic whencombined with α-MSH |
Oxacillin | 2048/>2048 | 4/>32 | 512/NA* |
Ciprofloxacin | 64/128 | 2/16 | 32/8 |
Tetracycline | 64/128 | 2/32 | 32/4 |
Gentamicin | 2048/>2048 | 2/32 | 1024/>64 |
Rifampicin | >256/512 | 8/>32 | >32/NA* |
Note: Fold reduction = (MBC50 of antibiotic alone/MBC50 in presence of α-MSH).
NA*means MBC90 not achieved.