Table 2. Antibacterial activity in µg mL−1 of the SMAMP polymers (Series 2).
Sample | B:D = 10∶0 | B:D = 9∶1 | B:D = 5∶5 | B:D = 1∶9 | ||||||||||||
c/µg mL−1 | MIC (optical) | MBC | MIC OD | MIC90 | MIC (optical) | MBC | MIC OD | MIC90 | MIC (optical) | MBC | MIC OD | MIC90 | MIC (optical) | MBC | MIC OD | MIC90 |
S. aureus ATCC25923 | 12.5 | 12.5 | 12.5 (38) | nd | 6.3 | 25 | 6.25 (29) | n.d. | 25 | 50 | 25 (8) | 25 | 50 | 200 | 50 (8) | 50 |
E. coli ATCC25922 | 25 | 25 | 25 (12) | nd | 12.5 | 25 | 12.5 (5) | 12.5 | >400 | >400 | >400 | >400 | 100 | n.b. | 100 (5) | 100 |
E. coli 9478 | 25 | 25 | 25 (11) | nd | 12.5 | 50 | 12.5 (9) | 12.5 | >400 | >400 | >400 | >400 | 100 | n.b. | 100 (4) | 100 |
Enterococcus faecalis T9 | 25 | 25 (13) | nd | 12.5 | 50 | 12.5 (33) | n.d. | 12.5 | 200 | 12.5 (5) | 12.5 | 25 | 200 | 25 (7) | 25 | |
MRSA ATCC43330 | 50 | 50 | 50 (5) | 50 | 12.5 | 12.5 | 12.5 (5) | 12.5 | 12.5 | 12.5 | 12.5 (10) | 12.5 | 12.5 | 25 | 12.5 (12) | n.d. |
Pseudomonas aeruginosaATCC 27853 | 25 | 25 (18) | nd | 50 | 100 | 50 (9) | 50 | >400 | >400 | >400 | >400 | 400 | 400 (7) | 400 | ||
Klebsiella pneumoniaeIUK 1230 | 12.5 | 12.5 (6) | 12.5 | 12.5 | 12.5 | 12.5 (4) | 12.5 | >400 | >400 | >400 | >400 | 400 | 400 (5) | 400 |
MIC optical = concentration at which no bacterial growth was visible, MIC OD = concentration at which the optical density measurement indicated minimal bacterial growth (calculated percentages of bacterial growth in brackets), MIC90 = concentration at which the bacterial growth was below 10% according to the optical density measurement, MBC = concentration at which the number of colony forming units was reduced by 99.9%; nd = not definable, blank cell = not determined.