Table 3. Cell selectivity of the SMAMP polymers expressed in terms of HC50/MIC90 selectivity and IC50/MIC90 selectivity.
Selectivity = HC50/MIC90 | Selectivity = IC50/MIC90 | |||||||||||||||
Sample | P:D = 10∶0 | P:D = 9∶1 | P:D = 5∶5 | P:D = 1∶9 | B:D = 10∶0 | B:D = 9∶1 | B:D = 5∶5 | B:D = 1∶9 | P:D = 10∶0 | P:D = 9∶1 | P:D = 5∶5 | P:D = 1∶9 | B:D = 10∶0 | B:D = 9∶1 | B:D = 5∶5 | B:D = 1∶9 |
S. aureus ATCC 25923 | 1 | 2 | 23 | 5 | 1 | 2 | 3 | 31 | 4 | 6 | 9 | 2 | 4 | 10 | 5 | 8 |
E. coli ATCC 25922 | 1 | 0 | 1 | 3 | 0 | 1 | 0 | 16 | 4 | 2 | 1 | 1 | 2 | 5 | 0 | 4 |
E. coli 9478 | 0 | 0 | 1 | 3 | 0 | 1 | 0 | 16 | 2 | 2 | 1 | 1 | 2 | 5 | 0 | 4 |
Enterococcus faecalis T9 | 2 | 1 | 23 | 10 | 0 | 1 | 6 | 63 | 8 | 3 | 9 | 4 | 2 | 5 | 9 | 15 |
MRSA ATCC 43330 | 1 | 2 | 12 | 5 | 0 | 1 | 6 | 125 | 4 | 6 | 4 | 2 | 1 | 5 | 9 | 30 |
Pseudomonas aeruginosa ATCC 27853 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 4 | 1 | 2 | 1 | 1 | 2 | 1 | 0 | 1 |
Klebsiella pneumoniae IUK 1230 | 0 | 0 | 1 | 3 | 1 | 1 | 0 | 4 | 2 | 2 | 1 | 1 | 4 | 5 | 0 | 1 |
IC50 | 102 | 78 | 217 | 402 | 53 | 60 | 113 | 378 | ||||||||
HC50 | 24 | 24 | 585 | 1028 | 7 | 12 | 78 | 1566 |