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. Author manuscript; available in PMC: 2014 May 24.
Published in final edited form as: Circ Res. 2013 May 24;112(11):1409–1411. doi: 10.1161/CIRCRESAHA.113.301406

Figure 1. Pathophysiological framework of HCM.

Figure 1

Solid arrows indicate experimental findings reported by Sequeira and coworkers. Open arrows indicate the consequences based on experimental evidence from other studies. (a) Impaired length-dependent activation can also be caused by PKA hypophosphorylation (i.e., of TnI). (b) HCM mutations may directly interfere with phosphorylation of myofilament PKA targets. (c) Only a subset of HCM mutations directly alter myofilament Ca sensitivity.