Table 3. Comparison of metabolically healthy and unhealthy subjects.

	Men			Women
Characteristics	Healthy n = 52	Unhealthy n = 139	p-value	Healthy n = 99	Unhealthy n = 168	p-value
HMW adiponectin (μg/ml)*	2.732 (1.784−3.683)	2.436 (1.442−3.941)	0.4	5.357 (3.606−6.722)	4.146 (2.421−5.795)	0.002
HOMA-IR*	0.525 (0.440−0.908)	1.510 (0.760−2.760)	0.0001	0.670 (0.450−1.105)	1.560 (0.885−2.715)	0.0001
Waist circumference (cm) °	89.1±11.2	100.9±13.1	0.0001	81.1±11.1	95.9±16.1	0.0001
BMI (kg/m2) °	25.1±4.5	28.9±5.1	0.0001	24.8±4.4	30.8±6.9	0.0001
Age (years) °	38.2±13.1	50.9±13.5	0.0001	41.3±13.1	53.5±13.7	0.0001

Data presented as median (interquartile range) * or mean (±SD) °.

Healthy – subjects without impaired glucose regulation, hypertension (blood pressure ≥130/80 mmHg), dyslipidaemia (triglycerides ≥1.7 mmol/L or HDL<1.03 in men or HDL<1.3 in women) and insulin resistance.

Unhealthy – subjects with impaired glucose regulation and/or hypertension and/or dyslipidaemia and/or insulin resistance.

Insulin resistance – was defined as the upper quartile of HOMA-IR in the whole study group (exempting subjects with previously known diabetes mellitus), the threshold of which in whole study group was found to be 1.92 (2.04 and 1.82 for men and women, resp.).