Table 4. Comparison of metabolically healthy and metabolically unhealthy subjects in terms of HMW adiponectin, HOMA-IR, age and waist circumference.

	BMI 18.5–24.9	BMI≥25 Healthy	BMI≥25 Unhealthy	p-value Healthy/ Unhealthy	BMI≥30 Healthy	BMI≥30 Unhealthy	p-value Healthy/ Unhealthy
HMW adiponectin (μg/ml)*
Men	3.297 n = 53	2.266 n = 27	2.163 n = 110	0.9	3.338 n = 6	1.957 n = 51	0.04
Women	5.151 n = 91	5.099 n = 39	3.824 n = 132	0.02	5.079 n = 13	3.091 n = 88	0.1
HOMA-IR°
Men	0.80±0.92	0.86±0.44	2.44±2.09	0.0001	1.08±0.61	3.15±2.39	0.006
Women	0.92±0.73	0.94±0.45	2.14±1.60	0.0001	1.14±0.42	2.53±1.71	0.0009
Age (years) °
Men	40.3±14.4	43.4±13.9	52.1±12.8	0.006	54.8±9.6	52.5±13.0	0.7
Women	43.3±14.6	44.5±12.4	54.7±12.8	0.0001	48.4±9.9	53.6±13.2	0.1
Waist circum-ference (cm) °
Men	84.1±9.1	97.1±9.2	104.6±11.1	0.0008	110.8±5.6	113.4±8.8	0.5
Women	75.0±6.4	91.6±8.0	101.2±13.7	0.0001	100.1±6.0	107.4±11.8	0.01

Data presented as median * or mean (±SD) °.

Healthy – subjects without impaired glucose regulation, hypertension (blood pressure ≥130/80 mmHg), dyslipidaemia (triglycerides ≥1.7 mmol/L or HDL<1.03 in men or HDL<1.3 in women) and insulin resistance.

Unhealthy – subjects with impaired glucose regulation and/or hypertension and/or dyslipidaemia and/or insulin resistance. Insulin resistance – was defined as the upper quartile of HOMA-IR in the whole study group (exempting subjects with previously known diabetes mellitus), the threshold of which in whole study group was found to be 1.92 (2.04 and 1.82 for men and women, resp.)