Figure 6. Nitric oxide and TNF-α mediate vascular dysfunction in paraquat-poisoned animals.

Effect of (A) L-NAME (300 µM), (B) L-NNA (1 µM), (C) L-NIL (10 µM) and (D) in vivo treatment with etanercept on phenylephrine-induced contraction in endothelium-intact aortic rings from control and paraquat-poisoned (PQ) animals. The values are mean ± SE from five experiments. **p<0.01; ***p<0.001.